Should be pretty easy plug and play. Since you already have a GPS antenna, you only need the adapters (1x power etc, 1x HF/ZF and 1x GPS) and access to a VAG-COM (or a nice dealer). You will also need to bridge the CAN-BUS signal at your TMC (virtually removing the TMC) and the US navigation DVD.
Check the cables/adapter section here for sources for the adapters. Also check out the RNS-E install pictures. Your's will be almost the same except that you don't need to look for a speed signal behind the instrument cluster.
If you get the US unit from the dealer you are all set. If you get the EU unit you will need to modify the map DVD (search this forum to see how).
Good luck...